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prdx2 a 2 mouse monoclonal (Santa Cruz Biotechnology)

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Santa Cruz Biotechnology prdx2 a 2 mouse monoclonal
Prdx2 A 2 Mouse Monoclonal, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/prdx2/PRX+II+Antibody/pm41932903-352-162-166
Average 93 stars, based on 19 article reviews

prdx2 a 2 mouse monoclonal - by Bioz Stars, 2026-10

93/100 stars

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Gentle:

Article Title: Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma
Article Snippet: .. Proteins were separated by 12% gel SDS-PAGE, transferred to polyvinylidene difluoride membranes, blocked with 5% (w/v) skim milk for 1 h, and co-incubated for 1 h with the primary antibody of PRDX1 (ab41906, Abcam, Cambridge, UK), PRDX2 (sc-23967, Santa Cruz Biotechnology, USA), PRDX3 (YT3873, ImmunoWay, Plano, TX, USA), PRDX4 (ab59542, Abcam, Cambridge, UK), PRDX5 (ab140926, Abcam, Cambridge, UK), or PRDX6 (sc-134478, Santa Cruz Biotechnology, USA) at room temperature with gentle agitation. ..

shRNA:

Article Title: Peroxiredoxin 2 contributes to the malignant phenotype of glioblastoma cells.
Article Snippet: Glioblastoma (GBM) is the most malignant primary brain tumor.. To adapt to intrinsic oxidative stress, GBM cells upregulate antioxidant systems.. Out of six peroxiredoxins (PRDX) involved in protecting cells from oxidative stress, PRDX1 and PRDX4 are proteins that have been attributed with GBM-promoting properties.

other:

Article Title: BMP signaling-driven osteogenesis is critically dependent on Prdx-1 expression-mediated maintenance of chondrocyte prehypetrophy.
Article Snippet: During endochondral ossification, cartilage template is eventually replaced by bone.. This process involves several well characterised, stereotypic, molecular and cellular changes in the cartilage primordia.. These steps involve transition from resting to proliferative and then prehypertrophic to finally hypertrophic cartilage.

Article Title: Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway.
Article Snippet: PURPOSE.. The flavonoids have potent antioxidant and free-radical scavenging properties and are beneficial in the prevention and treatment of ocular diseases including glaucoma.. The authors have previously reported that antiglaucoma agents could transcriptionally activate the antioxidant protein peroxiredoxin (PRDX)2.

Membrane:

Article Title: Isoquinolinequinone N-oxides with diverging mechanisms of action induce collateral sensitivity against multidrug resistant cancer cells.
Article Snippet: Multidrug resistance (MDR) is a major challenge in cancer research.. Collateral sensitizers, compounds that exploit the enhanced defense mechanisms of MDR cells as weaknesses, are a proposed strategy to overcome MDR.. Our previous work reported the synthesis of two novel Isoquinolinequinone (IQQ) N-oxides that induce collateral sensitivity in MDR ABCB1-overexpressing non-small cell lung cancer (NSCLC) and colorectal cancer cells.

Incubation:

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Study design and overview Experimental design for time course metabolomic profiling of male C57Bl6 wild-type and Prdx2− mice in vivo labeling, Biotin+ and Biotin−bead separation. Blood draws were performed at three different time points (8, 15, and 20 days) for each cohort with targeted metabolomic profiling. The subsequent analyses enable assessment of biochemical aging in vivo and the consequences of loss of Prdx2.

Journal: iScience

Article Title: The loss of peroxiredoxin 2 in mice disrupts the biochemical aging phenotype in erythrocytes

doi: 10.1016/j.isci.2025.114608

Figure Lengend Snippet: Study design and overview Experimental design for time course metabolomic profiling of male C57Bl6 wild-type and Prdx2− mice in vivo labeling, Biotin+ and Biotin−bead separation. Blood draws were performed at three different time points (8, 15, and 20 days) for each cohort with targeted metabolomic profiling. The subsequent analyses enable assessment of biochemical aging in vivo and the consequences of loss of Prdx2.

Article Snippet: All animal experiments were performed with C57BL/6J or Prdx2 knockout male mice from The Jackson Laboratory (Bar Harbor, ME).

Techniques: Metabolomic, In Vivo, Labeling

Unsupervised analysis of intracellular metabolomic profiles Clustering of plasma metabolomics profiles for the entire set of cohorts. (A) Clustering of WT and Prdx2 KO profiles at days 8, 15, or 20. (B) Clustering of the PRdx2 KO/WT ratios at the different time points.

Journal: iScience

Article Title: The loss of peroxiredoxin 2 in mice disrupts the biochemical aging phenotype in erythrocytes

doi: 10.1016/j.isci.2025.114608

Figure Lengend Snippet: Unsupervised analysis of intracellular metabolomic profiles Clustering of plasma metabolomics profiles for the entire set of cohorts. (A) Clustering of WT and Prdx2 KO profiles at days 8, 15, or 20. (B) Clustering of the PRdx2 KO/WT ratios at the different time points.

Article Snippet: All animal experiments were performed with C57BL/6J or Prdx2 knockout male mice from The Jackson Laboratory (Bar Harbor, ME).

Techniques: Metabolomic, Clinical Proteomics

Volcano plot comparisons between various pairwise experimental groups (A) Comparison of 3- versus 1-week-old RBCs showing similar trends for the WT and Prdx2 KO, particularly with increased ophthalmate and NaMN fold changes and decreased acyl-carnitines, alpha-ketoglutarate, and serotonin. There are notable metabolite differences in the Prdx2 KO mice RBCs that are also noted in other pairwise comparisons (e.g., uridine, inosine, tyrosine, and isoleucine). (B) Comparison of the youngest RBC cell population (day 8, Biotin−) versus the oldest, most heterogeneous RBC population (day 20, Biotin+). Very similar, concordant changes among metabolites are noted for the WT and Prdx2 KO alike. (C) Comparison of Prdx2 KO versus WT RBCs at 8, 15, and 20 days, respectively. These volcano plots highlight some of the genotypic differences in the in vivo aging study. Notable differences include increased intracellular fold changes in arginine, valine, and uridine. Although ophthalmate changes in Prdx2 KO and WT (A and B), quantitative response in the Prdx2 KO is different than the WT.

Journal: iScience

Article Title: The loss of peroxiredoxin 2 in mice disrupts the biochemical aging phenotype in erythrocytes

doi: 10.1016/j.isci.2025.114608

Figure Lengend Snippet: Volcano plot comparisons between various pairwise experimental groups (A) Comparison of 3- versus 1-week-old RBCs showing similar trends for the WT and Prdx2 KO, particularly with increased ophthalmate and NaMN fold changes and decreased acyl-carnitines, alpha-ketoglutarate, and serotonin. There are notable metabolite differences in the Prdx2 KO mice RBCs that are also noted in other pairwise comparisons (e.g., uridine, inosine, tyrosine, and isoleucine). (B) Comparison of the youngest RBC cell population (day 8, Biotin−) versus the oldest, most heterogeneous RBC population (day 20, Biotin+). Very similar, concordant changes among metabolites are noted for the WT and Prdx2 KO alike. (C) Comparison of Prdx2 KO versus WT RBCs at 8, 15, and 20 days, respectively. These volcano plots highlight some of the genotypic differences in the in vivo aging study. Notable differences include increased intracellular fold changes in arginine, valine, and uridine. Although ophthalmate changes in Prdx2 KO and WT (A and B), quantitative response in the Prdx2 KO is different than the WT.

Article Snippet: All animal experiments were performed with C57BL/6J or Prdx2 knockout male mice from The Jackson Laboratory (Bar Harbor, ME).

Techniques: Comparison, In Vivo

Highlights of metabolite alterations in glycolysis Glycolysis and closely associated sugar metabolite sub-network with select bar charts of significantly altered metabolites for Old (day 20/Biotin+) and Young (day 8/Biotin−) for WT and Prdx2 KO mice. Asterisks and associated bars demarcate significant differences (ANOVA, p < 0.05).

Journal: iScience

Article Title: The loss of peroxiredoxin 2 in mice disrupts the biochemical aging phenotype in erythrocytes

doi: 10.1016/j.isci.2025.114608

Figure Lengend Snippet: Highlights of metabolite alterations in glycolysis Glycolysis and closely associated sugar metabolite sub-network with select bar charts of significantly altered metabolites for Old (day 20/Biotin+) and Young (day 8/Biotin−) for WT and Prdx2 KO mice. Asterisks and associated bars demarcate significant differences (ANOVA, p < 0.05).

Article Snippet: All animal experiments were performed with C57BL/6J or Prdx2 knockout male mice from The Jackson Laboratory (Bar Harbor, ME).

Techniques:

Glutathione metabolism sub-network The glutathione sub-network with bar charts of select metabolites for Old (day 20/Biotin+) and Young (Day 8/Biotin−) for WT and Prdx2 KO mice. Asterisks and associated bars demarcate significant differences (ANOVA, p < 0.05).

Journal: iScience

Article Title: The loss of peroxiredoxin 2 in mice disrupts the biochemical aging phenotype in erythrocytes

doi: 10.1016/j.isci.2025.114608

Figure Lengend Snippet: Glutathione metabolism sub-network The glutathione sub-network with bar charts of select metabolites for Old (day 20/Biotin+) and Young (Day 8/Biotin−) for WT and Prdx2 KO mice. Asterisks and associated bars demarcate significant differences (ANOVA, p < 0.05).

Article Snippet: All animal experiments were performed with C57BL/6J or Prdx2 knockout male mice from The Jackson Laboratory (Bar Harbor, ME).

Techniques:

NAD metabolism sub-network Outline of key steps in NAD metabolism with bar charts of select metabolites for Old (day 20/Biotin+) and Young (day 8/Biotin−) for WT and Prdx2 KO mice. Asterisks and associated bars demarcate significant differences (ANOVA, p < 0.05).

Journal: iScience

Article Title: The loss of peroxiredoxin 2 in mice disrupts the biochemical aging phenotype in erythrocytes

doi: 10.1016/j.isci.2025.114608

Figure Lengend Snippet: NAD metabolism sub-network Outline of key steps in NAD metabolism with bar charts of select metabolites for Old (day 20/Biotin+) and Young (day 8/Biotin−) for WT and Prdx2 KO mice. Asterisks and associated bars demarcate significant differences (ANOVA, p < 0.05).

Article Snippet: All animal experiments were performed with C57BL/6J or Prdx2 knockout male mice from The Jackson Laboratory (Bar Harbor, ME).

Techniques:

Highlights of metabolite alterations in fatty acid and glycerolipid metabolism Outline of the key steps in lipid metabolism with bar charts of select metabolites for Older (day 20/Biotin+) and Younger (day 8/Biotin−) RBC from WT and Prdx2 KO mice. There is more variability and noise in the lipid profiles. A notable exception is GPC, which exhibits among the largest and most significant alterations (consistent with prior work). Choline and carnitine are also notably altered. Asterisks and associated bars demarcate significant differences (ANOVA, p < 0.05).

Journal: iScience

Article Title: The loss of peroxiredoxin 2 in mice disrupts the biochemical aging phenotype in erythrocytes

doi: 10.1016/j.isci.2025.114608

Figure Lengend Snippet: Highlights of metabolite alterations in fatty acid and glycerolipid metabolism Outline of the key steps in lipid metabolism with bar charts of select metabolites for Older (day 20/Biotin+) and Younger (day 8/Biotin−) RBC from WT and Prdx2 KO mice. There is more variability and noise in the lipid profiles. A notable exception is GPC, which exhibits among the largest and most significant alterations (consistent with prior work). Choline and carnitine are also notably altered. Asterisks and associated bars demarcate significant differences (ANOVA, p < 0.05).

Article Snippet: All animal experiments were performed with C57BL/6J or Prdx2 knockout male mice from The Jackson Laboratory (Bar Harbor, ME).

Techniques:

Metabolomic alterations over time across all groups Four different, general time course trajectories (MI, MD, VI, and XI) have been observed over the entire metabolome, with either monotonic changes or concave versus trajectories with peaks versus nadirs, respectively, occurring at approximately 2 weeks of RBC age. Selected metabolites from different metabolic pathways encapsulating the various patterns of metabolite concentration shifts that occur over time in WT and Prdx2 KO RBC. Red dotted box: glutathione-related metabolites. Blue dotted box: glycolytic metabolites. The dark red and blue lines correspond to Biotin− RBC. The light red and blue lines correspond to Biotin+ RBC. Significant associations (ANOVA, p < 0.05) for same age comparisons (days 8, 15, and 20), respectively, are denoted by ∗ for WT Biotin+ vs. WT Biotin−, ‡ for Prdx2 KO Biotin+ vs. Prdx2 KO Biotin−, • for WT Biotin+ vs. Prdx2 KO Biotin−, and ∧ for WT Biotin− vs. Prdx2 KO Biotin−.

Journal: iScience

Article Title: The loss of peroxiredoxin 2 in mice disrupts the biochemical aging phenotype in erythrocytes

doi: 10.1016/j.isci.2025.114608

Figure Lengend Snippet: Metabolomic alterations over time across all groups Four different, general time course trajectories (MI, MD, VI, and XI) have been observed over the entire metabolome, with either monotonic changes or concave versus trajectories with peaks versus nadirs, respectively, occurring at approximately 2 weeks of RBC age. Selected metabolites from different metabolic pathways encapsulating the various patterns of metabolite concentration shifts that occur over time in WT and Prdx2 KO RBC. Red dotted box: glutathione-related metabolites. Blue dotted box: glycolytic metabolites. The dark red and blue lines correspond to Biotin− RBC. The light red and blue lines correspond to Biotin+ RBC. Significant associations (ANOVA, p < 0.05) for same age comparisons (days 8, 15, and 20), respectively, are denoted by ∗ for WT Biotin+ vs. WT Biotin−, ‡ for Prdx2 KO Biotin+ vs. Prdx2 KO Biotin−, • for WT Biotin+ vs. Prdx2 KO Biotin−, and ∧ for WT Biotin− vs. Prdx2 KO Biotin−.

Article Snippet: All animal experiments were performed with C57BL/6J or Prdx2 knockout male mice from The Jackson Laboratory (Bar Harbor, ME).

Techniques: Metabolomic, Concentration Assay

Unsupervised analysis of mass action ratios (MARs) Linear discriminant analysis of the MAR in the RBC networks differentiates between the WT and Prdx2 KO as well as the homogeneous (Biotin−) and heterogeneous (Biotin+) aged RBCs.

Journal: iScience

Article Title: The loss of peroxiredoxin 2 in mice disrupts the biochemical aging phenotype in erythrocytes

doi: 10.1016/j.isci.2025.114608

Figure Lengend Snippet: Unsupervised analysis of mass action ratios (MARs) Linear discriminant analysis of the MAR in the RBC networks differentiates between the WT and Prdx2 KO as well as the homogeneous (Biotin−) and heterogeneous (Biotin+) aged RBCs.

Article Snippet: All animal experiments were performed with C57BL/6J or Prdx2 knockout male mice from The Jackson Laboratory (Bar Harbor, ME).

Techniques:

Immunohistochemistry detected the protein expression of Peroxiredoxin1 (Prdx1) and Prdx2 in brain tissues. (A) Prdx1 immunohistochemistry staining and expression levels in brain tissues; (B) Prdx2 immunohistochemistry staining and expression levels in brain tissues; ns, no significant difference, p > 0.05.

Journal: Brain and Behavior

Article Title: Lipopolysaccharide Upregulates Neuroinflammation, Oxidative Stress Responses, and Peroxiredoxins in Depression Models

doi: 10.1002/brb3.71231

Figure Lengend Snippet: Immunohistochemistry detected the protein expression of Peroxiredoxin1 (Prdx1) and Prdx2 in brain tissues. (A) Prdx1 immunohistochemistry staining and expression levels in brain tissues; (B) Prdx2 immunohistochemistry staining and expression levels in brain tissues; ns, no significant difference, p > 0.05.

Article Snippet: The membrane was blocked with 5% skim milk in TBST for 1 h at RT, followed by incubation with primary antibodies overnight at 4°C: GAPDH (Proteintech, No. 81640‐5‐RR, China), Prdx1 (Proteintech, No. 515816‐1‐AP, China), Prdx2 (Proteintech, No. 10545‐2‐AP, China), Prdx4 (ABonal, No. 4000001442, China).

Techniques: Immunohistochemistry, Expressing, Staining

RT‐qPCR detected the mRNA expression of Peroxiredoxin1 (Prdx1), Prdx2, Prdx4, and Prdx5 in brain tissues. (A) mRNA expression levels of Prdx1 in brain tissues; (B) mRNA expression levels of Prdx2 in brain tissues; (C) mRNA expression levels of Prdx4 in brain tissues; (D) mRNA expression levels of Prdx5 in brain tissues; * p < 0.05; ** p < 0.01.

Journal: Brain and Behavior

Article Title: Lipopolysaccharide Upregulates Neuroinflammation, Oxidative Stress Responses, and Peroxiredoxins in Depression Models

doi: 10.1002/brb3.71231

Figure Lengend Snippet: RT‐qPCR detected the mRNA expression of Peroxiredoxin1 (Prdx1), Prdx2, Prdx4, and Prdx5 in brain tissues. (A) mRNA expression levels of Prdx1 in brain tissues; (B) mRNA expression levels of Prdx2 in brain tissues; (C) mRNA expression levels of Prdx4 in brain tissues; (D) mRNA expression levels of Prdx5 in brain tissues; * p < 0.05; ** p < 0.01.

Techniques: Quantitative RT-PCR, Expressing

WB detected the protein expression of Peroxiredoxin1 (Prdx1), Prdx2, Prdx4, and Prdx5 in brain tissues. (A) Protein expression bands; (B) Prdx1 protein expression levels; (C) Prdx2 protein expression levels; (D) Prdx4 protein expression levels; (E) Prdx5 protein expression levels; ns, no significant difference, p > 0.05; * p < 0.05; ** p < 0.01.

Journal: Brain and Behavior

Article Title: Lipopolysaccharide Upregulates Neuroinflammation, Oxidative Stress Responses, and Peroxiredoxins in Depression Models

doi: 10.1002/brb3.71231

Figure Lengend Snippet: WB detected the protein expression of Peroxiredoxin1 (Prdx1), Prdx2, Prdx4, and Prdx5 in brain tissues. (A) Protein expression bands; (B) Prdx1 protein expression levels; (C) Prdx2 protein expression levels; (D) Prdx4 protein expression levels; (E) Prdx5 protein expression levels; ns, no significant difference, p > 0.05; * p < 0.05; ** p < 0.01.

Techniques: Expressing

The expression levels of Prdxs, reactive oxygen species (ROS), and nitric oxide (NO) in BV2 cells. (A) ROS fluorescence images; (B) ROS fluorescence levels in BV2 cells; (C) NO levels in BV2 cell supernatant; mRNA expression levels of Prdx1 (D), Prdx2 (E), Prdx4 (F), and Prdx5 (G) in BV2 cells; ns, no significant difference, p > 0.05; * p < 0.05; **** p < 0.0001.

Journal: Brain and Behavior

Article Title: Lipopolysaccharide Upregulates Neuroinflammation, Oxidative Stress Responses, and Peroxiredoxins in Depression Models

doi: 10.1002/brb3.71231

Figure Lengend Snippet: The expression levels of Prdxs, reactive oxygen species (ROS), and nitric oxide (NO) in BV2 cells. (A) ROS fluorescence images; (B) ROS fluorescence levels in BV2 cells; (C) NO levels in BV2 cell supernatant; mRNA expression levels of Prdx1 (D), Prdx2 (E), Prdx4 (F), and Prdx5 (G) in BV2 cells; ns, no significant difference, p > 0.05; * p < 0.05; **** p < 0.0001.

Techniques: Expressing, Fluorescence

WB detected the protein expression of Peroxiredoxin1 (Prdx1), Prdx2, Prdx4, and Prdx5 in BV2 cells. (A) Protein expression bands; protein expression levels of Prdx1 (B), Prdx2 (C), Prdx4 (D), and Prdx5 (E) in BV2 cells; ns, no significant difference, p > 0.05; * p < 0.05.

Journal: Brain and Behavior

Article Title: Lipopolysaccharide Upregulates Neuroinflammation, Oxidative Stress Responses, and Peroxiredoxins in Depression Models

doi: 10.1002/brb3.71231

Figure Lengend Snippet: WB detected the protein expression of Peroxiredoxin1 (Prdx1), Prdx2, Prdx4, and Prdx5 in BV2 cells. (A) Protein expression bands; protein expression levels of Prdx1 (B), Prdx2 (C), Prdx4 (D), and Prdx5 (E) in BV2 cells; ns, no significant difference, p > 0.05; * p < 0.05.

Techniques: Expressing

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prdx2 a 2 mouse monoclonal (Santa Cruz Biotechnology)

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